High-fiber diets reduce gut antimicrobial resistance.

Microbes resistant to antibiotics like tetracycline or aminoglycoside pose a global threat.

Antimicrobial resistance in humans is largely based on their gut microbiome, where microbes carry genetically encoded strategies to survive antibiotics.

A team led by the Agricultural Research Service (ARS) found that healthy adults who eat 8-10 grammes of soluble fibre daily have fewer antibiotic-resistant microbes in their guts.

Danielle Lemay, a molecular biologist at the ARS Western Human Nutrition Research Center in Davis, California, is the study's senior author.

We're not talking about an exotic diet, but a diverse, fiber-rich diet that some Americans eat.

By analysing 290 healthy adult participants, Dr. Lemay and her colleagues found that a diet high in soluble fibre (found in grains like barley and oats, legumes such as beans, lentils, and peas, as well as nuts and seeds)

low in animal protein was significantly correlated with lower levels of antimicrobial resistance genes (AMR) among gut microbes.

Diet diversity predicted low ARG levels more than fibre. Dr. Lemay suggested eating a variety of high-soluble-fiber foods for maximum benefit.


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